RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
SOD3
RNA ID
RNA Type
mRNA
Alteration Pattern
histone acetylation
Species
homo sapiens
Detection Methods
ROS Measurement; Mtt assay; EC-SOD Immunoprecipitation etc.
Target
NA
Pathway
JAK2/STAT3 signaling pathway; P44/42 ERK 1/2 signaling pathway
PubMed ID
Title
Regulation of Oxidative Stress in Pulmonary Artery Endothelium Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors
Year
2015
Function
"Exposure of HPAECs to scriptaid, N[4 [(hydroxyamino)carbonyl] phenyl]-a-(1-methylethyl)-benzeneacetamide, and trichostatin A for 24 hours induced expression of extracellular superoxide dismutase (EC-SOD), whereas expression of the prooxidant gene NADPH oxidase 4 was decreased. Induction of EC-SOD expression was attenuated by the Janus kinase 2 protein kinase inhibitor AG490 and by silencing Janus kinase 2 expression. Augmentation of EC-SOD expression using scriptaid was associated with increased histone H3 (Lys27) acetylation and H3 (Lys4) trimethylation at the gene promoter."